The toxic oral dose of ergocalciferol in the dog is 4 mg/kg. Deaths via renal or cardiovascular failure have been reported. With appropriate therapy, recovery is the usual outcome when no permanent damage has occurred. Other reported therapeutic measures include dialysis or the administration of citrates, sulfates, phosphates, corticosteroids, EDTA (ethylenediaminetetraacetic acid), and mithramycin via appropriate regimens. A loop diuretic (furosemide or ethacrynic acid) may be given with the saline infusion to further increase renal calcium excretion. Intravenous saline may quickly and significantly increase urinary calcium excretion. The first step should be hydration of the patient. Hypercalcemic crisis with dehydration, stupor, coma, and azotemia requires more vigorous treatment. The treatment of hypervitaminosis D with hypercalcemia consists in immediate withdrawal of the vitamin, a low calcium diet, generous intake of fluids, along with symptomatic and supportive treatment. Decline in the average rate of linear growth and increased mineralization of bones in infants and children (dwarfism). Bone demin- eralization (osteoporosis) in adults occurs concomitantly.Ĥ. This calculator calculates the iu (international unit) using mcg (microgram (mcg)) values. Widespread calcification of the soft tissues, including the heart, blood vessels, renal tubules, and lungs. Today, many countries still use the IU to measure vitamin D 1 IU of vitamin D is equivalent to 0.025 micrograms (abbreviated as either mcg or g) of cholecalciferol or ergocalciferol.1 Conversely, 1 microgram of vitamin D equals 40 IU of vitamin D. This Nature Made Vitamin D supplement is quality you can trust. Adults, take one Vitamin D3 Nature Made tablet daily with water and a meal. These Nature Made Vitamin D3 supplements contain 25mcg (1000 IU) of Vit D3 per serving. Impairment of renal function with polyuria, nocturia, polydipsia, hypercalciuria, reversible azotemia, hypertension, nephrocalcinosis, generalized vascular calcification, or irreversible renal insufficiency which may result in death.ģ. D3 vitamin is the body’s preferred form of Vitamin D to help maintain Vit D levels. Hypercalcemia with anorexia, nausea, weakness, weight loss, vague aches and stiffness, constipation, mental retardation, anemia, and mild acidosis.Ģ. The effects of administered vitamin D can persist for two or more months after cessation of treatment.ġ. Maintenance of a normal serum phosphorus level by dietary phosphate restriction and/or administration of aluminum gels as intestinal phosphate binders in those patients with hyperphosphatemia as frequently seen in renal osteodystrophy is essential to prevent metastatic calcification.Īdequate dietary calcium is necessary for clinical response to vitamin D therapy. In the treatment of hypoparathyroidism, intravenous calcium, parathyroid hormone, and/or dihydrotachysterol may be required.
When high therapeutic doses are used progress should be followed with frequent blood calcium determinations. IN VITAMIN D RESISTANT RICKETS THE RANGE BETWEEN THERAPEUTIC AND TOXIC DOSES IS NARROW. Dosage levels must be individualized and great care exercised to prevent serious toxic effects. Therapeutic dosage should be readjusted as soon as there is clinical improvement. Vitamin D administration from fortified foods, dietarysupplements, self-administered and prescription drug sources should be evaluated.
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